Models for drug absorption from the small intestine: where are we and where are we going?

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TitreModels for drug absorption from the small intestine: where are we and where are we going?
Type de publicationArticle de revue
AuteurBillat, Pierre-André , Roger, Emilie , Faure, Sébastien , Lagarce, Frédéric
PaysRoyaume-Uni
EditeurElsevier
VilleOxford
TypeArticle scientifique dans une revue à comité de lecture
Année2017
LangueAnglais
DateMai 2017
Numéro5
Pagination761-775
Volume22
Titre de la revueDrug Discovery Today
ISSN1359-6446
Résumé en anglais

The small intestine is a complex organ with movements, flora, mucus and flows. Despite this, the most widely used absorption models consider the organ a cylindrical monoepithelial tube. This review presents the recent evolution of models to take into consideration the complex nature of gut physiology. The most commonly encountered issues are ethical (in vivo models) and differences in drug transport as a result of a modified expression of drug transporters or metabolic enzymes compared with human (in vitro and in vivo models). Finally, this review discusses the way forward to reach an ideal equilibrium between reproducibility, predictability and efficiency for predicting permeability. The features of an ideal model are listed as a guideline for future development.

URL de la noticehttp://okina.univ-angers.fr/publications/ua15578
DOI10.1016/j.drudis.2017.01.007
Lien vers le document

http://www.sciencedirect.com/science/article/pii/S135964461730020X

Titre abrégéDrug Discovery Today