Titre | Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation |
Type de publication | Article de revue |
Auteur | Viault, Guillaume , Helesbeux, Jean-Jacques , Richomme, Pascal , Seraphin, Denis |
Editeur | Elsevier |
Type | Article scientifique dans une revue à comité de lecture |
Année | 2018 |
Langue | Anglais |
Date | 4 Juillet 2018 |
Numéro | 27 |
Pagination | 2627-2630 |
Volume | 59 |
Titre de la revue | Tetrahedron Letters |
ISSN | 00404039 |
Mots-clés | natural product, phenazine, quinone, semisynthesis, Vitamin E |
Résumé en anglais | A regioselective method for the semisynthesis of phenazine derivatives has been disclosed through an efficient IBX mediated ortho-quinone formation from vitamin E derivatives. High chemo- and regio-selectivity was observed during the oxidation step and the corresponding 5,6-ortho-quinones could react with various phenylenediamines. Thus, this methodology proves its interest as a concise semisynthetic pathway to phenazine-vitamin E hybrids with moderate to good yields. |
URL de la notice | http://okina.univ-angers.fr/publications/ua17306 |
DOI | 10.1016/j.tetlet.2018.05.011 |
Lien vers le document | www.sciencedirect.com/science/article/pii/S0040403918305902?via%3Dihub |
Titre abrégé | Tetrahedron lett. |