Vitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up

TitreVitamin K Antagonists and Cognitive Decline in Older Adults: A 24-Month Follow-Up
Type de publicationArticle de revue
AuteurBrangier, Antoine, Ferland, Guylaine, Rolland, Yves, Gautier, Jennifer, Féart, Catherine, Annweiler, Cédric
EditeurMDPI
TypeArticle scientifique dans une revue à comité de lecture
Année2018
LangueAnglais
Date24 Mai 2018
Numéro6
Pagination666
Volume10
Titre de la revueNutrients
ISSN2072-6643
Mots-clésAge Factors, Aged, Aged, 80 and over, Anticoagulants, Cognition, Cognition Disorders, Cognitive Aging, Cross-Sectional Studies, executive function, Female, Geriatric Assessment, Humans, Male, Mental Status and Dementia Tests, Prospective Studies, Risk Factors, Time Factors, Vitamin K
Résumé en anglais

Vitamin K participates in brain physiology. This study aimed to determine whether using vitamin K antagonists (VKAs), which interfere with the vitamin K cycle, were (i) cross-sectionally associated with altered cognitive performance, and (ii) independent predictors of cognitive changes in older adults over 24 months. Information was collected on the use of VKAs (i.e., warfarin, acenocoumarol, and fluindione) among 378 geriatric outpatients (mean, 82.3 ± 5.6 years; 60.1% female). Global cognitive performance and executive functions were assessed with Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) scores, respectively, at baseline and after 12 and 24 months of follow-up. Age, gender, body mass index, mean arterial pressure, disability, gait speed, comorbidities, atrial fibrillation, stroke, carotid artery stenosis, leukoaraiosis grade on computed tomography (CT) scan, psychoactive drugs, antidementia drugs, blood-thinning drugs (i.e., anticoagulants other than VKAs, antiplatelet medications), serum creatinine levels, and vitamin B12 concentrations were considered as potential confounders. Using VKAs was associated with lower (i.e., worse) FAB score at baseline (adjusted β = -2.1, = 0.026), and with a decrease in FAB score after 24 months (adjusted β = -203.6%, = 0.010), but not after 12 months ( = 0.659). Using VKAs was not associated with any change in MMSE score at baseline ( = 0.655), after 12 months ( = 0.603), or after 24 months ( = 0.201). In conclusion, we found more severe executive dysfunction at baseline and incident executive decline over 24 months among geriatric patients using VKAs, when compared with their counterparts.

URL de la noticehttp://okina.univ-angers.fr/publications/ua18699
DOI10.3390/nu10060666
Lien vers le document

https://www.mdpi.com/2072-6643/10/6/666

Autre titreNutrients
Identifiant (ID) PubMed29794977