Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis

TitreElevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis
Type de publicationArticle de revue
AuteurBastard, Jean-Philippe, Fellahi, Soraya, Audureau, Etienne, Layese, Richard, Roudot-Thoraval, Françoise, Cagnot, Carole, Mahuas-Bourcier, Valérie, Sutton, Angela, Ziol, Marianne, Capeau, Jacqueline, Nahon, Pierre, Calès, Paul
OrganismeANRS CO12 Cirvir study group
EditeurJohn Libbey Eurotext
TypeArticle scientifique dans une revue à comité de lecture
Année2018
LangueAnglais
DateSeptembre 2018
Numéro3
Pagination112-120
Volume29
Titre de la revueEuropean Cytokine Network
ISSN1952-4005
Mots-clésAdipokines, HCV, Hepatocellular carcinoma, immuno-inflammatory biomarkers
Résumé en anglais

An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. We selected 56 HCV1-infected patients who subsequently developed HCC (cases), and 96 controls matched for age, gender and diabetes, not developing HCC after a similar period. Adipokines and immuno-inflammatory biomarkers were determined on baseline frozen serum samples. Their influence on the occurrence of HCC was assessed using a mixed logistic regression model under univariate analysis and a backward stepwise procedure under multivariate analysis. The patients were mostly male (62.5%) with active HCV replication (83%) and had been followed for a median duration of 6.3 years during which 44.4% achieved a sustained viral response. Higher adiponectinemia levels were found in cases than in controls (P = 0.01). Levels of the immuno-inflammatory markers were similar in both groups except sTNFRII >5,000 pg/mL (52% cases versus 24% controls; P = 0.001). No marker was associated with histological steatosis. Under multivariate analysis, baseline adiponectin and sTNFRII levels were independently associated with the occurrence of HCC, alongside previous excessive alcohol intake and HCV viral load. High baseline circulating adiponectin and sTNFRII levels were associated with an increased risk of HCC in patients with HCV1 cirrhosis, independently of their HCV replication status.

URL de la noticehttp://okina.univ-angers.fr/publications/ua18904
DOI10.1684/ecn.2018.0413
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https://www.jle.com/fr/revues/ecn/e-docs/elevated_adiponectin_and_stnfri...

Titre abrégéEur. Cytokine Netw.
Identifiant (ID) PubMed30547888