UV-triggered photoinsertion of contrast agent onto polymer surfaces for in vivo MRI-visible medical devices

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TitreUV-triggered photoinsertion of contrast agent onto polymer surfaces for in vivo MRI-visible medical devices
Type de publicationArticle de revue
AuteurSchulz, Anita , Lemaire, Laurent
2, 3
, Bethry, Audrey, Allegre, Lucie, Cardoso, Maida, Bernex, Florence, Franconi, Florence
2, 3
, Goze-Bac, Christophe, Taillades, Hubert, Garric, Xavier , Nottelet, Benjamin
TypeArticle scientifique dans une revue à comité de lecture
Date9 Avril 2019
Titre de la revueMultifunctional Materials
ISSN 2399-7532
Résumé en anglais

Polymeric materials are largely employed for the manufacturing of implants for various reasons, but they are typically invisible by conventional imaging methods. To improve surgical procedure and postoperative implant follow-up though, biomaterials are needed which allow an accurate and efficient imaging. Here, we present a direct and versatile strategy that allows to covalently immobilize T1 magnetic resonance imaging (MRI) contrast agents at the surface of various clinically relevant polymeric biomaterials. An aryl-azide bearing complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and gadolinium (Gd) has been synthesized for easy photografting onto polymer surfaces. Polycaprolactone (PCL), polylactide (PLA), polyurethane (PU), polyetheretherketone (PEEK) and polypropylene (PP) have been selected as clinically relevant substrates and successfully functionalized with the photosensitive MRI probe DOTA/Gd. Following in vitro assessment of their biocompatibility and MRI visibility, commercial MRI-visible PP hernia repair meshes (MRI-meshes) have been prepared. MRI-meshes have been implanted in rats for in vivo evaluation of their imaging capacities over 1 month. Histological evaluation and Gd biodistribution studies have been carried out confirming the potential of this straightforward approach to simply yield imageable medical devices.

URL de la noticehttp://okina.univ-angers.fr/publications/ua19172
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Titre abrégéMultifunct. Mater.