Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency

DocumentFichier
Fichier pdf chargé le 24/05/2019 à 09:03:49

(version éditeur)
fichier
TitreDodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency
Type de publicationArticle de revue
AuteurUllio Gamboa, Gabriela Veroniva , Udobi, Kenea C, Dézard, Sophie, Perna, Marla K, Miles, Keila N, Costa, Narciso, Taran, Fréderic, Pruvost, Alain, Benoît, Jean-Pierre , Skelton, Matthew R, de Lonlay, Pascale, Mabondzo, Aloïse
EditeurFuture Medecine
TypeArticle scientifique dans une revue à comité de lecture
Année2019
LangueAnglais
DateJuin 2019
Numéro12
Pagination1579-1593
Volume14
Titre de la revueNanomedicine (Lond)
ISSN1748-6963
Mots-clésCreatine, creatine transporter deficiency, dodecyl creatine ester, drug delivery, microemulsion, nasal administration, neurotherapeutics for CTD
Résumé en anglais

Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodecyl creatine ester (DCE). DCE-ME was prepared by titration method. Novel object recognition (NOR) tests were performed before and after DCE-ME treatment on mice. Intranasal administration with DCE-ME improved NOR performance in mice. mice treated with DCE-ME had increased striatal ATP levels mainly in the striatum compared with vehicle-treated mice which was associated with increased expression of synaptic markers. These results highlight the potential value of DCE-ME as promising therapy for creatine transporter deficiency.

URL de la noticehttp://okina.univ-angers.fr/publications/ua19610
DOI10.2217/nnm-2019-0059
Lien vers le document

https://www.futuremedicine.com/doi/10.2217/nnm-2019-0059

Autre titreNanomedicine (Lond)
Identifiant (ID) PubMed31038003