Novel metal-based anticancer drugs: a new challenge in drug delivery

TitreNovel metal-based anticancer drugs: a new challenge in drug delivery
Type de publicationArticle de revue
AuteurLainé, Anne-Laure, Passirani-Malleret, Catherine
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2012
LangueAnglais
Date18/05/2012
Numéro4
Pagination420-6
Volume12
Titre de la revueCurrent opinion in pharmacology
ISSN1471-4973
Résumé en anglais

Since the serependitous discovery of the cisplatin antiproliferative activity, many efforts have focused on the design of potent metal-based drugs for oncology therapies. A large number of these complexes have been evaluated in vitro and in vivo and some have reached clinical trials. However, while metallodrug chemistry has developed to an advanced level, these emerging therapeutics have encountered new hurdles including poor water solubility and pharmacological deficiencies. Today, solutions to overcome these issues do not lie in synthesizing new anticancer drugs but in finding suitable drug delivery strategies. Over the past decades, various delivery systems have been developed including prodrug, ligand design and nanocarriers aimed at enhancing the performance profile of these novel metallodrugs.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3642
DOI10.1016/j.coph.2012.04.006