Microparticles and vascular dysfunction in obstructive sleep apnoea

TitreMicroparticles and vascular dysfunction in obstructive sleep apnoea
Type de publicationArticle de revue
AuteurTrzepizur, Wojciech , Martinez, Maria Carmen , Priou, Pascaline , Andriantsitohaina, Ramaroson , Gagnadoux, Frédéric
EditeurEuropean Respiratory Society
TypeArticle scientifique dans une revue à comité de lecture
DateJuil. 2014
Titre de la revueEuropean Respiratory Journal
Mots-clésAnimals, Atherosclerosis/physiopathology, Cardiovascular Diseases/physiopathology, Cell Membrane/metabolism, Cell-Derived Microparticles*, Endothelium, Humans, Inflammation/metabolism, Leukocytes/metabolism, Mice, Obstructive/physiopathology*, Oxidative Stress, Phenotype, Risk Factors, Sleep Apnea, Treatment Outcome, Vascular/physiopathology*
Résumé en anglais

Obstructive sleep apnoea (OSA) is independently associated with various cardiovascular diseases, including myocardial infarction and stroke. OSA may promote atherosclerosis risk factors such as hypertension, diabetes and dyslipidaemia, and may have direct proatherogenic effects on the vascular wall. A growing number of studies have recently focused on the role of microparticles (MPs) in the atherogenic process. MPs are small plasma membrane vesicles that can be released by a variety of vascular or blood cells, and contain both membrane and cytosolic elements. Case–control studies have shown that platelet-, endothelium- and leukocyte-derived MP levels are increased in OSA. Experimental evidence has demonstrated that MPs from OSA patients induce endothelial dysfunction, inflammation and vascular hyperreactivity when injected into mice. In this review, we provide an overview of the main characteristics of MPs, their expression in OSA and their potential role in the atherogenic process associated with OSA.

URL de la noticehttp://okina.univ-angers.fr/publications/ua10543
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Titre abrégéEur Respir J