Polyacetylenes from Radix et Rhizoma Notopterygii Incisi with an Inhibitory Effect on Nitric Oxide Production In Vitro

TitrePolyacetylenes from Radix et Rhizoma Notopterygii Incisi with an Inhibitory Effect on Nitric Oxide Production In Vitro
Type de publicationArticle de revue
AuteurBlunder, Martina, Liu, Xin, Kunert, Olaf, Winkler, Nora, Schinkovitz, Andreas , Schmiderer, Corinna, Novak, Johannes, Bauer, Rudolf
EditeurGeorg Thieme Verlag
TypeArticle scientifique dans une revue à comité de lecture
Année2014
LangueAnglais
DateJul-04-2014
Numéro05
Pagination415-8
Volume80
Titre de la revuePlanta Medica
ISSN0032-0943
Résumé en anglais

Notopterygium roots (Qiang Huo) have been used in traditional Chinese medicine for treating colds, inflammatory diseases like rheumatoid arthritis, and as an analgesic. The anti-inflammatory activity of the roots ofNotopterygium incisum has been evaluated by testing the inhibitory activity on nitric oxide production by inducible nitric oxide synthase. The apparent authenticity of the sample was checked by DNA sequence comparison. Using activity-guided isolation, different compounds were isolated and structurally characterized by means of NMR and mass spectroscopy. Eight polyacetylenes could be identified and were tested on their inhibitory activity on nitric oxide production in RAW 264.7 mouse macrophages using the Griess assay. Different 3-hydroxy allyl polyacetylenes exhibited significant activity (IC50: 8-acetoxyfalcarinol, 20.1 µM; falcarindiol, 9.2 µM; 9-epoxyfalcarindiol, 8.8 µM; and crithmumdiol, 23.6 µM).

URL de la noticehttp://okina.univ-angers.fr/publications/ua10577
DOI10.1055/s-0034-1368196
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Titre abrégéPlanta Med