Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds

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TitreIsoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds
Type de publicationArticle de revue
AuteurRopivia, Jacqueline , Derbré, Séverine , Rouger, Caroline , Pagniez, Fabrice, Le Pape, Patrice, Richomme, Pascal
PaysSuisse
EditeurMolecular Diversity Preservation International
VilleBâle
TypeArticle scientifique dans une revue à comité de lecture
Année2010
DateJan-09-2010
Numéro9
Pagination6476-6484
Volume15
Sectioncommunication
Titre de la revueMolecules
ISSN1420-3049
Mots-clésAntiparasitic, bisbenzylisoquinolines, isoquinoline alkaloids, Ranunculaceae, Thalictrum flavum
Résumé en anglais

Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities. Berberine was identified as a major component but its analogue, pseudoberberine, was isolated for the first time from this plant. As far as bisbenzylisoquinolines are concerned, thalfoetidine was also isolated and, besides, its nor- derivative, northalfoetidine, was identified as a new compound. Previously isolated alkaloids from Thalictrum species such as northalidasine, northalrugosidine, thaligosidine, thalicberine, thaliglucinone, preocoteine, O-methylcassythine and armepavine were newly described in the roots of T. flavum. Tertiary isoquinolines, and particularly bisbenzylisoquinolines, were found to be leishmanicidal against L. major. Thalfoetidine appeared as the most potent but its new nor- derivative northalfoetidine, as well as northalidasine, were of particular interest due to the fact that their potential leishmanicidal activity was not associated to a strong cytotoxicity.

URL de la noticehttp://okina.univ-angers.fr/publications/ua10612
DOI10.3390/molecules15096476
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http://www.mdpi.com/1420-3049/15/9/6476/