Anti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins

TitreAnti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins
Type de publicationCommunication
TypeCommunication avec actes dans un congrès
Année2014
LangueAnglais
Date du colloque31/08-04/09/2014
Titre du colloque62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research
Titre des actes ou de la revueBook of abstracts. In : Planta medica
Volume80(16)
PaginationP1L3
AuteurRouger, Caroline , Derbré, Séverine , Litaudon, Marc , Awang, Khalijah , Charreau, Béatrice , Richomme, Pascal
PaysPortugal
EditeurGeorg Thieme
VilleGuimarães
ISBN1439-0221
Mots-clésCalophyllaceae, Clusiaceae, Coumarins, immunomodulation, Inflammation
Résumé en anglais

Vascular endothelium plays a central role in the development of inflammatory and immune processes, which are involved in graft rejection [1]. Many Clusiaceae/Calophyllaceae species (pantropical plants) biosynthesize original polyphenolic compounds exhibiting antioxidant and anti-inflammatory properties [2 – 3]. Therefore, different Clusiaceae/Calophyllaceae polyphenols were selected in order to evaluate in vitro their anti-inflammatory and immunomodulatory potential towards Human Umbilical Vein Endothelial Cells (HUVECs). The VCAM-1, ICAM-1, E-selectin, HLA-I, HLA-II, HLA-E and MICA surface-expressions of HUVECs were evaluated by flow cytometry. It appeared that a few coumarins and one benzophenone at 10µM significantly inhibited the expression of several markers previously induced by TNF-α or IFN-γ cytokines, being more active that the immunosuppressive reference compound – zoledronic acid – at the same concentration. Among these active compounds, one phenylcoumarin isolated from the Malaysian Mesua lepidota T. Anderson (Calophyllaceae) was identified as a new one. By comparing biological effects with substitution patterns, preliminary structure-activity relationship was also established.

URL de la noticehttp://okina.univ-angers.fr/publications/ua10623
DOI10.1055/s-0034-1394661
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