Titre | Anti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins |
Type de publication | Communication |
Type | Communication avec actes dans un congrès |
Année | 2014 |
Langue | Anglais |
Date du colloque | 31/08-04/09/2014 |
Titre du colloque | 62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research |
Titre des actes ou de la revue | Book of abstracts. In : Planta medica |
Volume | 80(16) |
Pagination | P1L3 |
Auteur | Rouger, Caroline , Derbré, Séverine , Litaudon, Marc , Awang, Khalijah , Charreau, Béatrice , Richomme, Pascal |
Pays | Portugal |
Editeur | Georg Thieme |
Ville | Guimarães |
ISBN | 1439-0221 |
Mots-clés | Calophyllaceae, Clusiaceae, Coumarins, immunomodulation, Inflammation |
Résumé en anglais | Vascular endothelium plays a central role in the development of inflammatory and immune processes, which are involved in graft rejection [1]. Many Clusiaceae/Calophyllaceae species (pantropical plants) biosynthesize original polyphenolic compounds exhibiting antioxidant and anti-inflammatory properties [2 – 3]. Therefore, different Clusiaceae/Calophyllaceae polyphenols were selected in order to evaluate in vitro their anti-inflammatory and immunomodulatory potential towards Human Umbilical Vein Endothelial Cells (HUVECs). The VCAM-1, ICAM-1, E-selectin, HLA-I, HLA-II, HLA-E and MICA surface-expressions of HUVECs were evaluated by flow cytometry. It appeared that a few coumarins and one benzophenone at 10µM significantly inhibited the expression of several markers previously induced by TNF-α or IFN-γ cytokines, being more active that the immunosuppressive reference compound – zoledronic acid – at the same concentration. Among these active compounds, one phenylcoumarin isolated from the Malaysian Mesua lepidota T. Anderson (Calophyllaceae) was identified as a new one. By comparing biological effects with substitution patterns, preliminary structure-activity relationship was also established. |
URL de la notice | http://okina.univ-angers.fr/publications/ua10623 |
DOI | 10.1055/s-0034-1394661 |
Lien vers le document en ligne | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0034... |