Combined anti-AGEs and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav. (Solanaceae) fruits during ripening and related to their phytochemical compositions

TitreCombined anti-AGEs and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav. (Solanaceae) fruits during ripening and related to their phytochemical compositions
Type de publicationArticle de revue
AuteurHouda, M., Derbré, Séverine , Jedy, A., Tlili, N., Legault, J., Richomme, Pascal , Limam, F., Saidani-Tounsi, M.
EditeurIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
TypeArticle scientifique dans une revue à comité de lecture
Année2014
LangueAnglais
Pagination1029-1042
Volume13
Titre de la revueExcli Journal
ISSN1611-2156
Mots-clésadvanced glycation end-product (AGEs), in vitro and ex-vivo antioxidant activities, phenolic compounds, Solanum elaeagnifolium Cav
Résumé en anglais

Oxidative stress and advanced glycation end products (AGEs) are known as key factors for the development of diabetic complications such as retinopathy, cataract as well as atherosclerosis and neurodegenerative diseases, including Alzheimer’s diseases. In this context, natural products have been previously identified as promising sources for antioxidant and anti-glycation compounds. The current study focuses on the evaluation of antioxidant and glycation inhibitory activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanaceae) fruits at different ripening stages. The results showed that antioxidant and anti-AGEs activities were significantly influenced by solvents polarities and ripening stages of S. elaeagnifolium Cav. With one exception, methanolic extract of overripe S. elaeagnifolium Cav fruit showed important protective effects against cellular oxidative stress. The aqueous extract showed the highest ABTS+ scavenging ability. Principal component analysis showed that total phenolic and flavonoid contents correlated well with observed antioxidants and anti-glycation activities. These results bring attention to the possible use of S. elaeagnifolium Cav as a valuable source of bioactive compounds exhibiting antioxidant effects and potentially alleviating diabetic complications.

URL de la noticehttp://okina.univ-angers.fr/publications/ua10798
Lien vers le document

http://www.excli.de/vol13/Houda_Tlili_05092014_proof.pdf