First report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war

TitreFirst report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war
Type de publicationArticle de revue
AuteurRafei, Rayane
1, 2
, Dabboussi, Fouad , Hamze, Monzer , Eveillard, Matthieu , Lemarié, Carole, Mallat, Hassan , Rolain, Jean-Marc , Joly-Guillou, Marie-Laure , Kempf, Marie
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2014
LangueAnglais
DateAvr. 2014
Pagination21-23
Volume21
Titre de la revueInternational Journal of Infectious Diseases
ISSN1201-9712
Mots-clésAcinetobacter baumannii, Lebanon, Multidrug-resistant bacteria, NDM-1, Syrian civil war
Résumé en anglais

Objectives

The emergence of carbapenem-resistant Acinetobacter baumannii has been observed worldwide. We describe the first detection of A. baumannii carrying the blaNDM-1 gene in Lebanon, isolated from Syrian patients wounded during the civil war.

Methods

Four carbapenem-resistant A. baumannii strains isolated in 2012 in the Tripoli Government Hospital, Lebanon, from civilians wounded during the Syrian war, were analysed. Susceptibility was determined by disk diffusion testing, and resistance to carbapenems was confirmed by Etest. The presence of blaOXA-23-like, blaOXA-24-like, blaOXA-58-like, blaOXA-143-like, and blaNDM was investigated by PCR. Clonal relationships were studied by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and blaOXA-51 sequence-based typing.

Results

All isolates harboured the blaNDM-1 gene and were negative for other tested carbapenemases. They all belonged to the sequence type 85 and formed a single cluster by PFGE. Finally, blaOXA-51-like gene sequencing revealed the presence of the blaOXA-94 variant in all four isolates.

Conclusion

These findings show that Syria constitutes a reservoir for NDM-1-producing bacteria. These results also highlight the need for effective measures to stop the threatening spread of such strains.

URL de la noticehttp://okina.univ-angers.fr/publications/ua11006
DOI10.1016/j.ijid.2014.01.004
Lien vers le document

http://dx.doi.org/10.1016/j.ijid.2014.01.004

Titre abrégéInt J Infect Dis.