Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database

TitrePrognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database
Type de publicationArticle de revue
AuteurDesolneux, Grégoire, Burtin, Pascal, Lermite, Emilie , Bergamaschi, Roberto, Hamy, Antoine , Arnaud, Jean-Pierre
EditeurSpringer Verlag
TypeArticle scientifique dans une revue à comité de lecture
DateJuil. 2010
Titre de la revueInternational Journal of Colorectal Disease
Mots-clésAdult, Aged, Aged, 80 and over, Colorectal Neoplasms, Databases as Topic, Female, Humans, Kaplan-Meier Estimate, Lymph Nodes, Male, Middle Aged, Multivariate Analysis, Prognosis, Retrospective Studies
Résumé en anglais

PURPOSE: There is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. The aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients.

METHODS: This study included 362 patients operated in a single institution for Dukes A and B (node-negative) colorectal cancer. The median follow-up was 140 months. The prognostic value of 13 clinical and pathological parameters was investigated.

RESULTS: Multivariate analysis identified six independent prognostic factors: age at time of diagnosis (hazard ratio (HR) = 1.076), number of lymph nodes removed (HR = 0.948), perineural invasion (HR = 2.173), venous invasion (HR = 1.959), lymphatic vessel invasion (HR = 2.126), and T4 stage (HR = 5.876).

CONCLUSION: These parameters could be useful in identifying patients with high-risk node-negative colorectal cancer who should be presented to adjuvant therapy.

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Autre titreInt J Colorectal Dis
Identifiant (ID) PubMed20405293