Evolutionary Algorithm Based on New Crossover for the Biclustering of Gene Expression Data

TitreEvolutionary Algorithm Based on New Crossover for the Biclustering of Gene Expression Data
Type de publicationCommunication
TypeCommunication avec actes dans un congrès
Année2014
LangueAnglais
Date du colloque 21-23/08/2014
Titre du colloque9th IAPR International Conference
Titre des actes ou de la revuePattern Recognition in Bioinformatics
Pagination48–59
AuteurMaâtouk, Ons, Ayadi, Wassim, Bouziri, Hend, Duval, Béatrice
PaysSuède
EditeurSpringer
VilleStockholm
ISBN978-3-319-09191-4
Résumé en anglais

 

Microarray represents a recent multidisciplinary technology. It measures the expression levels of several genes under different biological conditions, which allows to generate multiple data. These data can be analyzed through biclustering method to determinate groups of genes presenting a similar behavior under specific groups of conditions.

This paper proposes a new evolutionary algorithm based on a new crossover method, dedicated to the biclustering of gene expression data. This proposed crossover method ensures the creation of new biclusters with better quality. To evaluate its performance, an experimental study was done on real microarray datasets. These experimentations show that our algorithm extracts high quality biclusters with highly correlated genes that are particularly involved in specific ontology structure.

URL de la noticehttp://okina.univ-angers.fr/publications/ua13428
DOI10.1007/978-3-319-09192-1_5