Models for drug absorption from the small intestine: where are we and where are we going?
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| Titre | Models for drug absorption from the small intestine: where are we and where are we going? |
| Type de publication | Article de revue |
| Auteur | Billat, Pierre-André , Roger, Emilie , Faure, Sébastien , Lagarce, Frédéric |
| Pays | Royaume-Uni |
| Editeur | Elsevier |
| Ville | Oxford |
| Type | Article scientifique dans une revue à comité de lecture |
| Année | 2017 |
| Langue | Anglais |
| Date | Mai 2017 |
| Numéro | 5 |
| Pagination | 761-775 |
| Volume | 22 |
| Titre de la revue | Drug Discovery Today |
| ISSN | 1359-6446 |
| Résumé en anglais | The small intestine is a complex organ with movements, flora, mucus and flows. Despite this, the most widely used absorption models consider the organ a cylindrical monoepithelial tube. This review presents the recent evolution of models to take into consideration the complex nature of gut physiology. The most commonly encountered issues are ethical (in vivo models) and differences in drug transport as a result of a modified expression of drug transporters or metabolic enzymes compared with human (in vitro and in vivo models). Finally, this review discusses the way forward to reach an ideal equilibrium between reproducibility, predictability and efficiency for predicting permeability. The features of an ideal model are listed as a guideline for future development. |
| URL de la notice | http://okina.univ-angers.fr/publications/ua15578 |
| DOI | 10.1016/j.drudis.2017.01.007 |
| Lien vers le document | http://www.sciencedirect.com/science/article/pii/S135964461730020X |
| Titre abrégé | Drug Discovery Today |