The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation

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TitreThe therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation
Type de publicationArticle de revue
AuteurCarradori, Dario
1, 2
, Eyer, Joël , Saulnier, Patrick , Préat, Véronique , des Rieux, Anne
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2017
LangueAnglais
DateAvril 2017
Pagination77-91
Volume123
Titre de la revueBiomaterials
ISSN1878-5905
Mots-clésnanomedicine, nanoparticles, nanotechnology, Neural stem cell differentiation, Neurodegenerative disease, Neurogenesis
Résumé en anglais

The discovery of adult neurogenesis drastically changed the therapeutic approaches of central nervous system regenerative medicine. The stimulation of this physiologic process can increase memory and motor performances in patients affected by neurodegenerative diseases. Neural stem cells contribute to the neurogenesis process through their differentiation into specialized neuronal cells. In this review, we describe the most important methods developed to restore neurological functions via neural stem cell differentiation. In particular, we focused on the role of nanomedicine. The application of nanostructured scaffolds, nanoparticulate drug delivery systems, and nanotechnology-based real-time imaging has significantly improved the safety and the efficacy of neural stem cell-based treatments. This review provides a comprehensive background on the contribution of nanomedicine to the modulation of neurogenesis via neural stem cell differentiation.

URL de la noticehttp://okina.univ-angers.fr/publications/ua15741
DOI10.1016/j.biomaterials.2017.01.032
Lien vers le document

http://www.sciencedirect.com/science/article/pii/S014296121730056X

Autre titreBiomaterials
Identifiant (ID) PubMed28161683