Titre | Tooth Extraction Locally Stimulates Proliferation of Multiple Myeloma in a Patient with Mandibular Localizations |
Type de publication | Article de revue |
Auteur | Kün-Darbois, Jean-Daniel , Quenel, Léonie, Badja, Smaïl, Chappard, Daniel |
Editeur | Karger Publishers |
Type | Article scientifique dans une revue à comité de lecture |
Année | 2017 |
Langue | Anglais |
Date | 2017 |
Pagination | 201-207 |
Volume | 138 |
Titre de la revue | Acta haematologica |
ISSN | 1421-9662 |
Mots-clés | Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents, Cell Proliferation, Female, Humans, mandible, Middle Aged, Multiple myeloma, Periodontitis, Plasma Cells, Tooth Extraction |
Résumé en anglais | OBJECTIVES: Multiple myeloma (MM) is characterized by the occurrence of osteolytic lesions. MM treatment usually involves antiresorptive drugs (mainly bisphosphonates). CASE REPORT: A patient with an MM presented osteolytic lesions of the mandible. Extraction of teeth 45 and 46 was performed 5 years after the diagnosis of periodontitis. Four months later, osteonecrosis of the jaw (ONJ) was diagnosed at the extraction site. X-ray showed an extension of osteolytic lesions on the right side, close to the extraction site, without modification of the lesions on the left side. Two months later, a curettage was performed because of a painful bone sequestration. X-ray showed an extension of the osteolytic lesions on the right side. RESULTS: Histological analysis found a vascularized plasmacytoma of the soft tissues around the ONJ. Analysis of the bone showed mixed lesions with osteonecrotic areas and living bone resorbed by active osteoclasts surrounding a plasmacytoma. The surface area of the osteolytic foci has considerably increased only close to the extraction site. CONCLUSIONS: Tooth extraction triggered an ONJ associated with bisphosphonate treatment. However, it also seemed to induce a considerable proliferation of plasma cells at the extraction site; we hypothesize that it is due to the increase in bone remodeling related to the surgical trauma. |
URL de la notice | http://okina.univ-angers.fr/publications/ua17666 |
DOI | 10.1159/000481425 |
Lien vers le document | |
Titre abrégé | Acta Haematol. |
Identifiant (ID) PubMed | 29207391 |