Glycosuria amount in response to hyperglycaemia and risk for diabetic kidney disease and related events in Type 1 diabetic patients

TitreGlycosuria amount in response to hyperglycaemia and risk for diabetic kidney disease and related events in Type 1 diabetic patients
Type de publicationArticle de revue
AuteurCarpentier, Charlyne , Dubois, Séverine , Mohammedi, Kamel, Belhatem, Narimène, Bouhanick, Béatrice, Rohmer, Vincent, Briet, Claire, Bumbu, Anisoara, Hadjadj, Samy, Roussel, Ronan, Potier, Louis, Velho, Gilberto, Marre, Michel
EditeurOxford University Press (OUP)
TypeArticle scientifique dans une revue à comité de lecture
Année2018
LangueAnglais
Date05 Juil. 2018
Numéro10
Pagination1731-1738
Volume34
Titre de la revueNephrology dialysis transplantation
ISSN1460-2385
Résumé en anglais

Background: Hyperglycaemia impairs tubulo-glomerular feedback. We tested whether variable tubulo-glomerular feedback during hyperglycaemia contributes to renal risk heterogeneity seen in Type 1 diabetes.

Methods: During the period 1990-92, we studied the tubulo-glomerular feedback in Type 1 diabetic patients at high or low renal risk [21 of 54 with glomerular hyperfiltration and/or microalbuminuria against 11 of 55 with normal glomerular filtration rate (GFR) and urinary albumin despite uncontrolled diabetes]. The GFR, effective renal plasma flow, mean arterial pressure and fractional reabsorptions of glucose, osmols, sodium and lithium were measured sequentially during normo- and hyperglycaemia. All patients were followed up until 2016 for incident proteinuria, estimated GFR <60 mL/min/1.73 m2, doubling of serum creatinine, end-stage renal disease or all-cause death.

Results: Glycaemia increased from 6.1 ± 1.3 to 15.1 ± 1.9 mmol/L in both high-risk and low-risk patients. Glycosuria was lower in the high- versus low-risk patients: 0.34 ± 0.25 versus 0.64 ± 0.44 mmol/min (P = 0.03). Both groups displayed similar kidney function during normoglycaemia. Hyperglycaemia increased more importantly GFR and fractional reabsorptions, and pre-glomerular vasodilatation in the high- than in the low-risk patients (all P < 0.05). Over 21 years, 31.5% high- versus 12.7% low-risk patients developed endpoints (adjusted P = 0.006). In a multi-adjusted survival analysis of patients having undergone renal tests, each 0.10 mmol/min glycosuria during hyperglycaemia reduced the outcome risk by 0.72 (95% confidence interval 0.49-0.97, P = 0.03).

Conclusions: Reduced tubulo-glomerular feedback and glycosuria during hyperglycaemia indicate high renal risk for Type 1 diabetic patients. Inter-individual variability in tubulo-glomerular feedback activity determines renal risk in Type 1 diabetes.

URL de la noticehttp://okina.univ-angers.fr/publications/ua18379
DOI10.1093/ndt/gfy197
Titre abrégéNephrol. Dial. Transplant.
Identifiant (ID) PubMed29982607