Patient Blood Management in Major Orthopedic Surgery: Less Erythropoietin and More Iron?

TitrePatient Blood Management in Major Orthopedic Surgery: Less Erythropoietin and More Iron?
Type de publicationArticle de revue
AuteurRineau, Emmanuel , Stoyanov, Alexandra, Samson, Emmanuel, Hubert, Laurent, Lasocki, Sigismond
EditeurLippincott, Williams & Wilkins
TypeArticle scientifique dans une revue à comité de lecture
Année2017
LangueAnglais
DateNovembre 2017
Numéro5
Pagination1597–1599
Volume125
Titre de la revueAnesthesia & Analgesia
ISSN0003-2999
Résumé en anglais

Erythropoietin (EPO) is proposed preoperatively to reduce blood transfusion in anemic patients (hemoglobin < 13 g/dL) scheduled for a major orthopedic surgery. New intravenous iron formulations allow infusion of higher doses, increasing EPO response. In that context, we evaluated in a before-after study (n = 62 and 65 patients for each period) a new EPO administration protocol (2 injections 4 and 3 weeks before surgery, and a third if hemoglobin <13 g/dL instead of <15 g/dL 2 weeks before surgery). After this protocol implementation, the mean (standard deviation) number of EPO injections decreased from 2.8 (0.5) to 2.2 (0.4)/patient (P < .0001) without changing transfusion rates (3% in the 2 periods).

URL de la noticehttp://okina.univ-angers.fr/publications/ua18455
DOI10.1213/ANE.0000000000002086
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Titre abrégéAnesthesia & Analgesia