Nonalcoholic Fatty Liver Disease and the Gut Microbiome

TitreNonalcoholic Fatty Liver Disease and the Gut Microbiome
Type de publicationArticle de revue
AuteurBoursier, Jérôme , Diehl, Anna Mae
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2016
LangueAnglais
DateMai 2016
Numéro2
Pagination263-75
Volume20
Titre de la revueClinics in Liver Disease
ISSN1557-8224
Mots-clésAnimals, Carcinoma, Hepatocellular, Gastrointestinal Microbiome, Humans, Liver Cirrhosis, Liver neoplasms, Non-alcoholic Fatty Liver Disease, Severity of Illness Index
Résumé en anglais

Recent progress has allowed a more comprehensive study of the gut microbiota. Gut microbiota helps in health maintenance and gut dysbiosis associates with chronic metabolic diseases. Modulation of short-chain fatty acids and choline bioavailability, lipoprotein lipase induction, alteration of bile acid profile, endogenous alcohol production, or liver inflammation secondary to endotoxemia result from gut dysbiosis. Modulation of the gut microbiota by pre/probiotics gives promising results in animal, but needs to be evaluated in human before use in clinical practice. Gut microbiota adds complexity to the pathophysiology of nonalcoholic fatty liver disease but represents an opportunity to discover new therapeutic targets.

URL de la noticehttp://okina.univ-angers.fr/publications/ua18939
DOI10.1016/j.cld.2015.10.012
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Titre abrégéClin Liver Dis
Identifiant (ID) PubMed27063268