Specialist Advice Support for Management of Severe Hereditary Angioedema Attacks: A Multicenter Cluster-Randomized Controlled Trial

TitreSpecialist Advice Support for Management of Severe Hereditary Angioedema Attacks: A Multicenter Cluster-Randomized Controlled Trial
Type de publicationArticle de revue
AuteurJavaud, Nicolas, Fain, Olivier, Durand-Zaleski, Isabelle, Launay, David, Bouillet, Laurence, Gompel, Anne, Sobel, Alain, Woimant, Maguy, Rabetrano, Hasina, Petrovic, Tomislav, Lapostolle, Frederic, Boccon-Gibod, Isabelle, Reuter, Paul-Georges, Bertrand, Philippe, Mezaour, Malha, Coppere, Brigitte, Floccard, Bernard, Kanny, Gisele, Baker, Elinor, Martin, Ludovic , Vicaut, Eric, Adnet, Frederic
TypeArticle scientifique dans une revue à comité de lecture
DateAoût 2018
Titre de la revueAnnals of emergency medicine
Résumé en anglais

STUDY OBJECTIVE: Hereditary angioedema is a rare disease associated with unpredictable, recurrent attacks of potentially life-threatening edema. Management of severe attacks is currently suboptimal because emergency medical teams are often unaware of new specific treatments. The objective of this trial is to test whether a dedicated national telephone care-management strategy would reduce resource use during severe hereditary angioedema attacks.

METHODS: We conducted a cluster-randomized multicenter prospective trial of patients with a documented diagnosis of hereditary angioedema (type I, II or FXII hereditary angioedema). Participants were enrolled between March 2013 and June 2014 at 8 participating reference centers. The randomized units were the reference centers (clusters). Patients in the intervention arm were given a national free telephone number to call in the event of a severe attack. Emergency physicians in the SOS-hereditary angiœdema (SOS-HAE) call center were trained to advise or prescribe specific treatments. The primary outcome was number of admissions for angioedema attacks. Economic evaluation was also performed.

RESULTS: We included 100 patients in the SOS-HAE group and 100 in the control group. During the 2 years, there were 2,368 hereditary angioedema attacks among 169 patients (85%). Mean number of hospital admissions per patient in the 2-year period was significantly greater in the usual-practice group (mean 0.16 [range 0 to 2] versus 0.03 [range 0 to 1]); patient risk difference was significant: -0.13 (95% confidence interval -0.22 to -0.04; P=.02). Probabilistic sensitivity graphic analysis indicated a trend toward increased quality-adjusted life-years in the SOS-HAE group.

CONCLUSION: A national dedicated call center for management of severe hereditary angioedema attacks is associated with a decrease in hospital admissions and may be cost-effective if facilities and staff are available to deliver the intervention alongside existing services.

URL de la noticehttp://okina.univ-angers.fr/publications/ua19919
Lien vers le document


Titre abrégéAnn Emerg Med
Identifiant (ID) PubMed29503044