Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode

TitreAssociation between hypovitaminosis D and cognitive inhibition impairment during major depression episode
Type de publicationArticle de revue
AuteurBelzeaux, R, Annweiler, Cédric , Bertrand, J A, Beauchet, Olivier, Pichet, S, Jollant, Fabrice, Turecki, Gustavo, Richard-Devantoy, Stéphane
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2018
LangueAnglais
DateJanvier 2018
Numéro1
Pagination302-305
Volume225
Titre de la revueJournal of Affective Disorders
ISSN1573-2517
Mots-clésAdolescent, Adult, Aged, Cognition, Cognition Disorders, Cross-Sectional Studies, Dépression, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Seasons, Tandem Mass Spectrometry, Vitamin D, Vitamin D Deficiency, Young Adult
Résumé en anglais

BACKGROUND: Major depressive episode (MDE) has been associated with cognitive functioning alteration and hypovitaminosis D (hypoVD), but the relationship between hypoVD, depression, and cognition is not well understood. We aimed to compare patient with MDE with or without hypoVD in regard of cognitive functioning.

METHODS: 91 patients (38.5 years old, 65.9% female) with MDE were included in a cross-sectional study and were evaluated with a complete cognitive battery. None of the participants were medicated at the time of the inclusion. Serum 25-hydroxyvitamin D was measured using LC-MS/MS method, and hypovitaminosis was defined as 25OHD < 50nmol/L. Covariates were gender, season of dosage, first MDE onset, age, body mass index and depression severity RESULTS: Patients with hypoVD demonstrated a higher stroop intereference index time underscoring that means low cognitive inhibition ability. Mutiple logistic regression confirmed that hypoVD was significantly associated with high stroop interference time index after controlling by gender, season of dosage, first MDE onset, age, body mass index and depression severity.

CONCLUSION: Our results suggest that patient with MDE having hypoVD may be more prone to cognitive impairment.

URL de la noticehttp://okina.univ-angers.fr/publications/ua19940
DOI10.1016/j.jad.2017.08.047
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https://www.sciencedirect.com/science/article/abs/pii/S0165032717301349?...

Titre abrégéJ Affect Disord
Identifiant (ID) PubMed28843080