Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum

TitreRelationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum
Type de publicationArticle de revue
AuteurLefthériotis, Georges , Abraham, Pierre , Le Corre, Yannick, Le Saux, Olivier, Henrion, Daniel , Ducluzeau-Fieloux, Pierre-Henri
2, 3
, Prunier, Fabrice , Martin, Ludovic
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2011
Date2011/11
Numéro5
Pagination1390 - 1394
Volume54
Titre de la revueJournal of Vascular Surgery
ISSN0741-5214
Résumé en anglais

ObjectivesPseudoxanthoma elasticum (PXE) is an inherited metabolic disease characterized by elastic fiber fragmentation and calcification in the cutaneous, ophthalmologic, and vascular tissues. Cardiovascular manifestations such as peripheral arterial disease (PAD) are frequent in PXE. Because of the changes in the elastic properties and medial calcification of the arterial wall in PXE, the impact of the arterial remodeling on the ankle brachial index (ABI), a well-established diagnostic method for the detection and follow-up of PAD, remains to be determined in this disease. Methods This was a cross-sectional, comparative, open study, which took place at the PXE Consultation Center, University Hospital of Angers. The subjects were 53 patients (mean age, 49 ± 14 years; 35 females) with PXE clinically proven on the basis of established criteria (skin changes, angioid streaks, and skin biopsy). The ABI at rest, symptoms of intermittent claudication (IC), carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (c-f PWV), compliance (CC), and β stiffness index were measured in a single-center cohort. Results Forty-five percent of the PXE patients had an ABI ≤0.90, but only one patient had an ABI >1.40. IC was found in 23% of the patients with an ABI ≤0.90. There were no significant differences between the patients with a low and normal ABI in terms of IMT (P = .566) or β stiffness index (P = .194), but differences were significant for c-f PWV (P = .010) and CC (P = .011). Adjusted multivariate linear regression for the Framingham-Laurier score showed that patients with a low ABI had less compliant carotid arteries (B = 0.318, P = .039). Conclusions PAD detected by a low ABI is very frequent in PXE, although with limited prevalence of symptomatic claudication. Unexpectedly, ABI was low in such calcifying PAD and associated with lower CC, independently of atherosclerosis risk factors. These findings demonstrate that PXE represents a unique monogenic model of PAD in which the specific arterial wall remodeling could change the diagnostic value of the ABI to detect PAD.

URL de la noticehttp://okina.univ-angers.fr/publications/ua304
DOI10.1016/j.jvs.2011.04.041
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http://dx.doi.org/10.1016/j.jvs.2011.04.041