Bone metastasis: Histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. A review

TitreBone metastasis: Histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. A review
Type de publicationArticle de revue
AuteurChappard, Daniel , Bouvard, Béatrice, Baslé, Michel-Félix , Legrand, Erick , Audran, Maurice
EditeurElsevier Masson
TypeArticle scientifique dans une revue à comité de lecture
Année2011
LangueAnglais
Date2011/06
Numéro309
Pagination65 - 75
Volume95
Titre de la revueMorphologie
ISSN1286-0115
Mots-clésBone malignancy, bone metastasis, Cancer secondaire des os, Métastase osseuse, Ostéolyse, osteolysis, Ostéosclérose, Osteosclerosis, Pathophysiology, Physiopathologie
Résumé en anglais

SummaryThe development of a bone metastasis involves interactions between the tumor cells, the bone marrow microenvironment and the bone cells themselves. A better understanding of the pathophysiological changes occurring in bone metastasis can be obtained from histopathological examination of invaded specimens. This review focuses on the main molecular mechanisms implied in the localization and growth of malignant cells in the bone marrow. The corresponding histologic developmental stages are illustrated both in osteolytic (or mixed metastasis) or in the osteosclerotic forms by histological analysis, immunohistochemistry and microcomputed tomographic analysis of bone samples. In both cases, the malignant cells find a “fertile soil” in the bone marrow microenvironment. They use the growth factors released by bone cells for the coupling between osteoclasts/osteoblasts to promote their own development. In turn, they elaborate a variety of cytokines that can promote osteoclastogenesis (PTHrP, IL-1, IL-6…) or on the contrary, other growth factors that can boost the osteoblastic activity (ET1, IGFs). A “vicious circle” occurs between the malignant cells and the bone cells leading to the radiological expression of the metastasis.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3321
DOI10.1016/j.morpho.2011.02.004
Lien vers le document

http://dx.doi.org/10.1016/j.morpho.2011.02.004