Impact of vasopressin analogues on the gut mucosal microcirculation

TitreImpact of vasopressin analogues on the gut mucosal microcirculation
Type de publicationArticle de revue
AuteurAsfar, Pierre , Bracht, Hendrik, Radermacher, Peter
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2008
LangueAnglais
Date2008/06
Numéro2
Pagination351 - 358
Volume22
Titre de la revueBest Practice & Research Clinical Anaesthesiology
ISSN1521-6896
Mots-clésclinical studies, experimental, Haemodynamics, Microcirculation, septic shock, splanchnic circulation, terlipressin, vasopressin
Résumé en anglais

Given the controversial experimental and clinical data reported in the literature, up to now it is rather difficult to draw a definitive conclusion on the effects of V1 agonists on splanchnic haemodynamics. Nevertheless, it must be underscored that most of the experimental studies assessing the effects of low dose V1 agonist infusion in hyperdynamic models did not demonstrate any detrimental effect on splanchnic haemodynamics both at macro- and microcirculatory levels. Interestingly, all the reported studies focused on macro- and microcirculatory haemodynamics, while only some also addressed the local oxygenation and metabolism. In clinical studies in patients with septic shock, data are accumulating regarding the absence of clinically relevant side effects in the splanchnic region when vasopressin is used, but conversely little is known about the safety of terlipressin, mainly because of the small number of patients studied. Thus, the absence of clinically harmful effect does not exclude covert splanchnic ischaemia, which may counterbalance the beneficial systemic effects.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3458
DOI10.1016/j.bpa.2008.02.009
Lien vers le document

http://dx.doi.org/10.1016/j.bpa.2008.02.009