Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?

TitreEthyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
Type de publicationArticle de revue
AuteurWagner, Florian, Asfar, Pierre , Georgieff, Michael, Radermacher, Peter, Wagner, Katja
EditeurBioMed Central
TypeArticle scientifique dans une revue à comité de lecture
Année2012
LangueAnglais
Date2012/02/01
Numéro1
Pagination1 - 3
Volume16
Titre de la revueCritical Care
ISSN1364-8535
Mots-clésEmergency Medicine, Intensive / Critical Care Medicine
Résumé en anglais

N-acetylcysteine is the classical antidote for acetaminophen overdose-induced hepatotoxicity, but its efficacy is limited by the need for early and only temporary treatment. Therefore, Yang and colleagues tested the hypothesis of whether ethyl pyruvate - another anti-inflammatory and antioxidant compound, which they had previously shown to protect against liver injury of various other etiologies - may allow circumventing these limitations. While ethyl pyruvate improved liver regeneration when administered early and during a limited period only, the opposite response was present both after delayed as well as prolonged treatment. The authors concluded that prolonged anti-inflammatory treatment is detrimental after acetaminophen intoxication-induced liver damage. On the one hand, this research paper confirms the need for biomarkers to monitor organ recovery after acetaminophen. On the other hand, this paper adds to the ongoing discussion on the usefulness of ethyl pyruvate as a resuscitation fluid in the critically ill.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3600
DOI10.1186/cc11153
Lien vers le document

http://dx.doi.org/10.1186/cc11153