Of mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)

TitreOf mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)
Type de publicationArticle de revue
AuteurWagner, Katja, Georgieff, Michael, Asfar, Pierre , Calzia, Enrico, Knöferl, Markus-W., Radermacher, Peter
EditeurBioMed Central
TypeArticle scientifique dans une revue à comité de lecture
Année2011
LangueAnglais
Date2011/12/01
Numéro2
Volume15
Titre de la revueCritical Care
ISSN1364-8535
Mots-clésEmergency Medicine, Intensive / Critical Care Medicine
Résumé en anglais

Whether the hydrogen sulfide (H2S)-induced metabolic depression observed in awake rodents exists in larger species is controversial. Therefore, Derwall and colleagues exposed anesthetized and ventilated sheep to incremental H2S concentrations by means of an extracorporeal membrane oxygenator. H2S caused pulmonary vasoconstriction and metabolic acidosis at the highest concentration studied. Oxygen uptake and carbon dioxide production remained in the physiological range. The authors concluded that, beyond the effect of temperature, H2S hardly modifies metabolism at all. Since the highest H2S concentration caused toxic side effects (possibly due to an inhibition of mitochondrial respiration), the therapeutic use of inhaled H2S should be cautioned.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3603
DOI10.1186/cc10079
Lien vers le document

http://dx.doi.org/10.1186/cc10079