Microparticles harboring sonic hedgehog: Role in angiogenesis regulation

TitreMicroparticles harboring sonic hedgehog: Role in angiogenesis regulation
Type de publicationArticle de revue
AuteurSoleti, Raffaella
1, 2
, Martinez, Maria Carmen
1, 2
EditeurTaylor & Francis
TypeArticle scientifique dans une revue à comité de lecture
Pagination293 - 295
Titre de la revueCell adhesion & migration
Mots-clésadhesion, Anti-angiogenic factor, Capillary-like formation, membrane-derived, Pro-angiogenic mediators, Rho A, sonic hedgehog
Résumé en anglais

Sonic Hedgehog (Shh) is a morphogen involved in embryonic development of nervous system. Also, it has been shown that recombinant Shh can modulate angiogenesis under ischemic conditions. However, angiogenic effects of endogenous Shh have not been completely elucidated. Using small membrane-derived vesicles expressing Shh (MPsShh+), we have shown that, although MPsShh+ decrease endothelial cell proliferation and migration, they are able to favour angiogenesis through the increase of both endothelial cell adhesion and expression of pro-angiogenenic factors. Activation of proteins implicated in cell adhesion, such as Rho A, as well as upregulation of pro-angiogenic factors were sensitive to inhibition of Shh pathway. Although whole composition of MPsShh+ needs to be characterized to understand potential effects of MPsShh+, these results highlight a new role of MPsShh+ in vascular pathophysiology and may have significant implication for therapy in pathologies associated with altered angiogenesis in order to re-address angiogenic switch.

URL de la noticehttp://okina.univ-angers.fr/publications/ua365
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