Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms

DocumentFichier
Fichier pdf chargé le 07/11/2017 à 11:43:45
Fichier confidentiel (accès sur demande uniquement)
(version éditeur)
Request
TitrePost-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms
Type de publicationArticle de revue
AuteurPerrier, Thomas, Saulnier, Patrick , Fouchet, Florian , Lautram, Nolwenn , Benoît, Jean-Pierre
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2010
LangueAnglais
Date30/08/2010
Numéro1-2
Pagination204-9
Volume396
Titre de la revueInternational Journal of Pharmaceutics
ISSN1873-3476 / 0378-5173
Mots-clésAmphiphilic phospholipids, Electrokinetic measurements, Lipid nanocapsules, Post-insertion, Soft-particle analysis
Résumé en anglais

Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms.

URL de la noticehttp://okina.univ-angers.fr/publications/ua3703
DOI10.1016/j.ijpharm.2010.06.019
Lien vers le document

http://www.sciencedirect.com/science/article/pii/S0378517310004473?via%3...