Unusual Aspergillus species in patients with cystic fibrosis

TitreUnusual Aspergillus species in patients with cystic fibrosis
Type de publicationArticle de revue
AuteurSymoens, Françoise, Haase, Gerhard, Pihet, Marc , Carrère, Jacqueline, Beguin, Hugues, Degand, Nicolas, Mely, Laurent, Bouchara, Jean-Philippe
EditeurOxford University Press
TypeArticle scientifique dans une revue à comité de lecture
PaginationS10 - S16
Titre de la revueMedical Mycology
Résumé en anglais

Poorly sporulating Aspergillus isolates from patients with cystic fibrosis (CF) are generally identified in routine procedures as Aspergillus spp. In this study, we identified and characterized 11 isolates belonging to two unusual Aspergillus species of the section Fumigati (A. lentulus and Neosartorya pseudofischeri) recovered from four different patients. Aspergillus lentulus was found occasionally during a 10-year follow-up study of one CF patient colonized by A. fumigatus. Neosartorya pseudofischeri was isolated from three patients followed in different European hospitals. This species was recovered from two sputum samples of one patient, and from four successive samples of the two other patients, suggesting that it may be responsible for chronic colonization. Both species were isolated together with A. fumigatus. Isolates from both species did not grow at 50°C, and DNA sequence analysis, together with further morphological observations permitted identification at the species level. Growth at different temperatures and antifungal susceptibility were also investigated. All the isolates of N. pseudofischeri exhibited a very low susceptibility to voriconazole (VRZ) whereas a very low susceptibility to VRZ and amphotericin B was seen with the A. lentulus isolates.

URL de la noticehttp://okina.univ-angers.fr/publications/ua4963
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