Synthesis, characterization and antifungal activity of a series of manganese(II) and copper(II) complexes with ligands derived from reduced N,N′-O-phenylenebis(salicylideneimine)

TitreSynthesis, characterization and antifungal activity of a series of manganese(II) and copper(II) complexes with ligands derived from reduced N,N′-O-phenylenebis(salicylideneimine)
Type de publicationArticle de revue
AuteurBelaïd, Sabrina, Landreau, Anne , Djebbar, Safia, Benali-Baïtich, Ouassini, Bouet, Gilles , Bouchara, Jean-Philippe
PaysPays-Bas
EditeurElsevier
VilleAmsterdam
TypeArticle scientifique dans une revue à comité de lecture
Année2008
LangueAnglais
Date2008/01
Numéro1
Pagination63 - 69
Volume102
Titre de la revueJournal of Inorganic Biochemistry
ISSN0162-0134
Mots-clésAntifungal Activity, complexes, Copper, Manganese, Reduced Schiff bases
Résumé en anglais

A series of manganese(II) and copper(II) complexes with reduced Schiff bases derived from o-phenylenediamine has been prepared and characterized by elemental analysis, TG measurements, ESR, magnetic measurements, FTIR, UV–Visible spectra and conductivity. These complexes were found to be [MnL(H2O)n] and [CuL](H2O)n species with n = 0–2. Their antifungal activity was evaluated on different human fungi including yeasts of the Candida genus (C. albicans, C. glabrata, C. tropicalis and C. parapsilopsis) some opportunistic moulds belonging to the Aspergillus (A. fumigatus, A. terreus and A. flavus), Scedosporium genus (S. apiospermum and S. prolificans) and some dermatophytes (M. gypseum, M. persicolor, T. mentagrophytes, M. canis and T. tonsurans). The manganese complexes showed a significant growth inhibition of the dermatophytes tested and fungi of the genus Scedosporium. This is very interesting as these fungi are usually poorly susceptible to current antifungal including Amphotericin B and Itraconazole chosen as reference in this study.

URL de la noticehttp://okina.univ-angers.fr/publications/ua53
DOI10.1016/j.jinorgbio.2007.07.001
Lien vers le document

http://dx.doi.org/10.1016/j.jinorgbio.2007.07.001