In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery

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TitreIn vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery
Type de publicationArticle de revue
AuteurRivera-Rodriguez, Gustavo R, Lollo, Giovanna , Montier, Tristan, Benoît, Jean-Pierre , Passirani-Malleret, Catherine, Alonso, Maria José, Torres, Dolores
TypeArticle scientifique dans une revue à comité de lecture
Date2013 Dec 15
Titre de la revueInternational Journal of Pharmaceutics
Mots-clésAnimals, Antineoplastic Agents, Asparagine, Cell Line, Tumor, Chemistry, Pharmaceutical, Drug Carriers, Drug Delivery Systems, Glioma, Mice, Nanocapsules, Particle Size, Taxoids, Tissue Distribution
Résumé en anglais

Here, we report the in vivo proof of-concept of a novel nanocarrier, poly-l-asparagine (PASN) nanocapsules, as an anticancer targeted drug delivery system. The nanocapsules were loaded with the fluorescent marker DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate) and also with the model drug docetaxel to evaluate the biodistribution and efficacy profiles in healthy and glioma-bearing mice, respectively. Regardless of their cargo, the nanocapsules presented a size close to 180 nm, a surface charge around -40 mV and an encapsulation efficiency of 75-90%. The biodistribution study in healthy mice showed that PASN nanocapsules led to a two- and three-fold increment in the mean residence time (MRT) and area under the curve (AUC) values, respectively, compared to those of a non-polymeric nanoemulsion. Finally, the efficacy/toxicity study indicated that the encapsulated drug was as efficacious as the commercial formulation (Taxotere(®)), with the additional advantage of being considerably less toxic. Overall, these results suggest the potential of PASN nanocapsules as drug nanocarriers in anticancer therapy.

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Autre titreInt J Pharm
Identifiant (ID) PubMed24140546