Anti-Ku antibodies: Clinical, genetic and diagnostic insights

TitreAnti-Ku antibodies: Clinical, genetic and diagnostic insights
Type de publicationArticle de revue
AuteurBelizna, Cristina, Henrion, Daniel , Beucher, Alain, Lavigne, Christian, Ghaali, A., Levesque, H.
TypeArticle scientifique dans une revue à comité de lecture
Pagination691 - 4
Titre de la revueAutoimmunity Reviews
Mots-clésAntigens, Nuclear/genetics/immunology/metabolism, Autoantibodies/immunology/metabolism, Autoimmune Diseases/diagnosis/epidemiology/genetics/immunology, Connective Tissue Diseases/diagnosis/epidemiology/genetics/immunology, Continental Population Groups, DNA-Activated Protein Kinase/metabolism, DNA-Binding Proteins/genetics/immunology/metabolism, Genetic Predisposition to Disease, Humans, Nuclear Proteins/metabolism, Prevalence, Risk Factors
Résumé en anglais

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.

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Titre abrégéAutoimmun Rev