Arterial stiffness and stroke in sickle cell disease

TitreArterial stiffness and stroke in sickle cell disease
Type de publicationArticle de revue
AuteurBelizna, Cristina, Loufrani, Laurent , Ghali, Alaa, Lahary, A., Primard, E., Louvel, J. P, Henrion, Daniel , Levesque, H., Ifrah, Norbert
EditeurAmerican Heart Association
TypeArticle scientifique dans une revue à comité de lecture
Année2011
LangueAnglais
Date2011
Numéro4
Pagination1129 - 30
Volume43
Titre de la revueStroke
ISSN1524-4628
Mots-clésAdolescent, Adult, Anemia, Sickle Cell/complications/physiopathology/ultrasonography, Female, Humans, Male, Stroke/etiology/physiopathology/ultrasonography, Ultrasonography, Doppler, Transcranial, Vascular Stiffness
Résumé en anglais

BACKGROUND AND PURPOSE: Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. METHODS: Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured. RESULTS: Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (P<0.05) and especially in patients with stroke (P<0.05). CONCLUSIONS: These data suggest that transcranial Doppler and arterial stiffness might be associated to stroke in adult patients with sickle cell disease.

URL de la noticehttp://okina.univ-angers.fr/publications/ua8173
DOI10.1161/STROKEAHA.111.635383
Lien vers le document

http://dx.doi.org/10.1161/STROKEAHA.111.635383

Titre abrégéStroke