Early compaction at day 3 may be a useful additional criterion for embryo transfer

TitreEarly compaction at day 3 may be a useful additional criterion for embryo transfer
Type de publicationArticle de revue
AuteurLe Cruguel, Sebastien, Ferré-L’Hotellier, Véronique, Moriniere, C., Lemerle, S., Reynier, Pascal , Descamps, Philippe, May-Panloup, Pascale
EditeurSpringer Verlag
TypeArticle scientifique dans une revue à comité de lecture
Pagination683 - 90
Titre de la revueJournal of assisted reproduction and genetics
Mots-clésAdult, Blastomeres/cytology/physiology, Cell Fusion, Cell Shape/physiology, Cleavage Stage, Ovum/cytology/metabolism/physiology/ultrastructure, Embryo Implantation/physiology, Embryo Transfer/methods, Embryo, Mammalian/cytology/metabolism/physiology, Female, Fertilization in Vitro, Humans, Infertility/diagnosis/therapy, Intercellular Junctions/physiology, Predictive Value of Tests, Pregnancy, Pregnancy Rate, Prospective Studies, quality control, Time Factors
Résumé en anglais

PURPOSE: The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryonic compaction at day 3 as a marker of the chances of implantation. METHODS: We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos. RESULTS: Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44% versus 29.5%, p = 0.01), and when at least one compacted embryo is transferred (44% versus 31%, p < 0.05). The analysis of our single embryo transfers shows that the implantation rates are significantly better for compacted embryos (50% versus 30%, p < 0.05) (OR 2.98; CI 1.02-5.28). CONCLUSION: Thus, early compaction, sometimes observed at day 3, may serve as a useful additional criterion for selecting the embryos transferred.

URL de la noticehttp://okina.univ-angers.fr/publications/ua8225
Lien vers le document


Titre abrégéJ Assist Reprod Genet