Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors

TitreEndocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors
Type de publicationArticle de revue
AuteurIllouz, Frédéric, Braun, D., Briet, Claire, Schweizer, U., Rodien, Patrice
EditeurBioScientifica
TypeArticle scientifique dans une revue à comité de lecture
Année2014
LangueAnglais
Date2014
Numéro3
PaginationR91 - 9
Volume171
Titre de la revueEuropean Journal of Endocrinology
ISSN1479-683X
Mots-clésAnimals, Antineoplastic Agents/adverse effects, Endocrine System/drug effects/metabolism, Humans, Protein Kinase Inhibitors/adverse effects, Thyroid Diseases/chemically induced/metabolism, Thyroid Function Tests/methods, Thyroid Gland/drug effects/metabolism, Thyroid Hormones/metabolism
Résumé en anglais

Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy.

URL de la noticehttp://okina.univ-angers.fr/publications/ua8235
DOI10.1530/EJE-14-0198
Lien vers le document

http://dx.doi.org/10.1530/EJE-14-0198

Titre abrégéEur J Endocrinol