High-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions

TitreHigh-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions
Type de publicationArticle de revue
AuteurGuérin-Moreau, Morgane, Lefthériotis, Georges , Le Corre, Yannick, Etienne, Maxime, Amode, R., Hamel, Jean-François, Croué, Anne, Le Saux, Olivier, Machet, L., Martin, Ludovic
EditeurWiley
TypeArticle scientifique dans une revue à comité de lecture
Année2013
LangueAnglais
Date2013
Numéro6
Pagination1233 - 9
Volume169
Titre de la revueThe British journal of dermatology
ISSN1365-2133
Mots-clésAdolescent, Aged, Case-Control Studies, Female, Humans, Middle Aged, Observer Variation, Pseudoxanthoma Elasticum/pathology/ultrasonography, Sensitivity and Specificity, Skin/pathology/radiation effects/ultrasonography, Sunlight/adverse effects, Sunscreening Agents/pharmacology, Young Adult
Résumé en anglais

BACKGROUND: In most patients pseudoxanthoma elasticum (PXE) manifests with yellowish cutaneous papules and dermal elastorrhexis on skin biopsy. In a small number of cases there are no skin manifestations on clinical examination, and establishing a diagnosis of PXE in such patients is challenging. High-frequency ultrasonography (HFUS) may be of use in predicting skin areas that would yield a biopsy specimen positive for elastorrhexis. OBJECTIVES: To describe characteristics of clinically visible PXE skin using HFUS, and to evaluate its relevance for diagnosis. METHODS: HFUS was performed in a cohort of patients with PXE and in controls at a referral centre. HFUS images of PXE skin were compared with those of other conditions. Five operators blind-scored multiple HFUS images of photoprotected or photoexposed skin from patients with PXE and controls. The diagnostic indices (sensitivity, specificity, likelihood ratios, interobserver agreement) were calculated. RESULTS: The HFUS changes considered as diagnostic for PXE were primarily oval homogeneous hypoechogenic areas in the mid-dermis. The size of these areas closely matched the extent of the histological changes. The sensitivity and specificity of the diagnostic items and interobserver agreement were high, particularly in photoprotected skin. Dermal hypoechogenicity in PXE could be related to high hydration of connective tissue due to the presence of glycosaminoglycans despite elastic fibre mineralization. CONCLUSIONS: HFUS provides suggestive images of PXE skin lesions. HFUS should now be studied to determine whether it is a potentially valuable technique for the noninvasive identification of elastorrhexis in patients with PXE in whom skin involvement is clinically minimal or absent.

URL de la noticehttp://okina.univ-angers.fr/publications/ua8268
DOI10.1111/bjd.12545
Lien vers le document

http://dx.doi.org/10.1111/bjd.12545

Titre abrégéBr J Dermatol