Mitochondrial energetics and therapeutics

TitreMitochondrial energetics and therapeutics
Type de publicationArticle de revue
AuteurWallace, D. C, Fan, W., Procaccio, Vincent
EditeurAnnual Reviews
TypeArticle scientifique dans une revue à comité de lecture
Pagination297 - 348
Titre de la revueAnnual Review of Pathology Mechanisms of Disease
Mots-clésAnimals, DNA, Mitochondrial/genetics, Energy Metabolism/physiology, Humans, Mitochondria/physiology, Mitochondrial Diseases/genetics/physiopathology/therapy, Therapeutics/trends
Résumé en anglais

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic diseases, cancer, and aging. All these clinical manifestations arise from the central role of bioenergetics in cell biology. Although genetic therapies are maturing as the rules of bioenergetic genetics are clarified, metabolic therapies have been ineffectual. This failure results from our limited appreciation of the role of bioenergetics as the interface between the environment and the cell. A systems approach, which, ironically, was first successfully applied over 80 years ago with the introduction of the ketogenic diet, is required. Analysis of the many ways that a shift from carbohydrate glycolytic metabolism to fatty acid and ketone oxidative metabolism may modulate metabolism, signal transduction pathways, and the epigenome gives us an appreciation of the ketogenic diet and the potential for bioenergetic therapeutics.

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Titre abrégéAnnu Rev Pathol