Skin vascular resistance in the standing position increases significantly after 7 days of dry immersion

TitreSkin vascular resistance in the standing position increases significantly after 7 days of dry immersion
Type de publicationArticle de revue
AuteurNavasiolava, Nastassia, de Germain, V., Levrard, Thibaud , Larina, I. M, Kozlovskaya, I. B, Diquet, Bertrand , Le Bouil, Anne , Custaud, Marc-Antoine, Fortrat, Jacques-Olivier
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2011
LangueAnglais
DateFevr. 2011
Numéro1-2
Pagination64-68
Volume160
Titre de la revueAutonomic Neuroscience
ISSN1872-7484
Mots-clésAutonomic Nervous System, Cardiovascular control, Cutaneous circulation, Cutaneous vasoconstrictor response, Local circulatory control, Orthostasis, Spontaneous baroreflex, Weightlessness
Résumé en anglais

Actual and simulated microgravity induces hypovolemia and cardiovascular deconditioning, associated with vascular dysfunction. We hypothesized that vasoconstriction of skin microcirculatory bed should be altered following 7 days of simulated microgravity in order to maintain cardiovascular homeostasis during active standing. Eight healthy men were studied before and after 7 days of simulated microgravity modeled by dry immersion (DI). Changes of plasma volume and orthostatic tolerance were evaluated. Calf skin blood flow (laser-Doppler flowmetry), ECG and blood pressure signal during a 10-min stand test were recorded, and skin vascular resistance, central hemodynamics, baroreflex sensitivity and heart rate variability were estimated. After DI we observed increased calf skin vascular resistance in the standing position (12.0 +/- 1.0 AU-after- vs. 6.8 +/- 1.4 AU-before), while supine it was unchanged. Cardiovascular deconditioning was confirmed by greater tachycardia on standing and by hypovolemia (-16 +/- 3% at day 7 of DI). Total peripheral resistance and indices of cardiovascular autonomic control were not modified. In conclusion, unchanged autonomic control and total peripheral resistance suggest that increased skin vasoconstriction to standing involves rather local mechanisms-as venoarteriolar reflex-and might compensate insufficient vasoconstriction of other vascular beds.

URL de la noticehttp://okina.univ-angers.fr/publications/ua8415
DOI10.1016/j.autneu.2010.10.003
Lien vers le document

http://dx.doi.org/10.1016/j.autneu.2010.10.003

Titre abrégéAuton Neurosci