Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection

TitreTreg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection
Type de publicationArticle de revue
AuteurJarry, Ulrich, Donnou, Sabrina, Vincent, Marie, Jeannin, Pascale , Pineau, Laurent, Frémaux, Isabelle, Delneste, Yves , Couez, Dominique
EditeurElsevier
TypeArticle scientifique dans une revue à comité de lecture
Année2014
LangueAnglais
Date2014/02/15
Numéro1–2
Pagination35 - 42
Volume267
Titre de la revueJournal of Neuroimmunology
ISSN0165-5728
Mots-clésCNS tumor, CpG-ODN, NK cells, Treg
Résumé en anglais

Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the establishment of a memory antitumor immune response in 60% of them. This protective effect was associated with a recruitment of NK cells and, to a lesser extent, of dendritic cells, B cells and T lymphocytes. NK cell depletion abolished the protective effect of the treatment, confirming a major role of NK cells in brain tumor elimination. Each treatment used alone failed to protect brain tumor bearing mice, revealing the therapeutic benefit of combining Treg depletion and local CpG-ODN injection.

URL de la noticehttp://okina.univ-angers.fr/publications/ua9215
DOI10.1016/j.jneuroim.2013.12.005
Lien vers le document

http://dx.doi.org/10.1016/j.jneuroim.2013.12.005